Educational information, not medical advice.See how evidence is graded

5HTP

What is it? 5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid that is used as a dietary supplement to increase serotonin levels in the

Home

What is it? 5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid that is used as a dietary supplement to increase serotonin levels in the brain. What are the mechanisms by which it works for medicinal purposes? 5-HTP works by increasing the production of serotonin in the brain. This is achieved by acting as a precursor to serotonin, converting into the neurotransmitter once it crosses the blood-brain barrier. Serotonin plays a role in regulating mood, sleep, and appetite, among other functions. What are the active ingredients that are important for its medicinal properties? The active ingredient in 5-HTP is the amino acid 5-HTP. What forms does it come in? 5-HTP is available in various forms such as capsules, tablets, and liquids. What if there’s an imbalance or deficiency? If there is an imbalance or deficiency in 5-HTP, symptoms can include depression, anxiety, insomnia, and migraines. When was it first used for medicinal purposes? 5-HTP was first used for medicinal purposes in the mid-20th century. Summary 5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid that is used as a dietary supplement to increase serotonin levels in the brain. It works by acting as a precursor to serotonin, converting into the neurotransmitter once it crosses the blood-brain barrier. The active ingredient in 5-HTP is the amino acid 5-HTP. It is available in various forms such as capsules, tablets, and liquids and was first used for medicinal purposes in the mid-20th century. 5-HTP has been shown to help treat conditions such as depression, insomnia, migraines, fibromyalgia, anxiety, and appetite control. Foods that are rich in 5-HTP include grains, meat, dairy products, fruits, and vegetables. A lack of 5-HTP can lead to symptoms such as depression, anxiety, insomnia, and migraines. Possible side effects of 5-HTP include nausea, diarrhea, vomiting, stomach pain, drowsiness, headache, and sexual dysfunction. The recommended daily dose of 5-HTP is 100-300

Helps

Which conditions and symptoms can it help? 5-HTP has been shown to help treat the following conditions and symptoms: Depression Insomnia Migraines Fibromyalgia Anxiety Appetite control Obesity Regulate the production of serotonin by the central nervous system

5HTP

Quick Facts

  • Pregnancy & breastfeeding: Not assessed for this entry. Ask your doctor or midwife before use.

Educational information, not medical advice — ask your doctor or midwife.

Track this remedy in the app

Track 5HTP with reminders and record whether it helped, in the app.

Download on the App StoreGet it on Google Play

What is it?

5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid that is used as a dietary supplement to increase serotonin levels in the brain.

What are the mechanisms by which it works for medicinal purposes?

5-HTP works by increasing the production of serotonin in the brain. This is achieved by acting as a precursor to serotonin, converting into the neurotransmitter once it crosses the blood-brain barrier. Serotonin plays a role in regulating mood, sleep, and appetite, among other functions.

What are the active ingredients that are important for its medicinal properties?

The active ingredient in 5-HTP is the amino acid 5-HTP.

What forms does it come in?

5-HTP is available in various forms such as capsules, tablets, and liquids.

What if there’s an imbalance or deficiency?

If there is an imbalance or deficiency in 5-HTP, symptoms can include depression, anxiety, insomnia, and migraines.

When was it first used for medicinal purposes?

5-HTP was first used for medicinal purposes in the mid-20th century.

Summary

5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid that is used as a dietary supplement to increase serotonin levels in the brain. It works by acting as a precursor to serotonin, converting into the neurotransmitter once it crosses the blood-brain barrier. The active ingredient in 5-HTP is the amino acid 5-HTP. It is available in various forms such as capsules, tablets, and liquids and was first used for medicinal purposes in the mid-20th century. 5-HTP has been shown to help treat conditions such as depression, insomnia, migraines, fibromyalgia, anxiety, and appetite control. Foods that are rich in 5-HTP include grains, meat, dairy products, fruits, and vegetables. A lack of 5-HTP can lead to symptoms such as depression, anxiety, insomnia, and migraines. Possible side effects of 5-HTP include nausea, diarrhea, vomiting, stomach pain, drowsiness, headache, and sexual dysfunction. The recommended daily dose of 5-HTP is 100-300

Evidence grades and traditional-use labels are explained in our methodology. Nothing here is medical advice.

Reviewed by the HealisticMD editorial team How we grade evidence →

The published evidence for 5HTP is weak or absent. That usually means no controlled trial has tested it, not that a trial found it ineffective — the two are different, and we grade only what has been published.

Remedies related to 5HTP

The evidence behind this remedy, in one page

What it is typically used for, usual dose, cautions, and the study behind it where real trial data exists.

One email with the summary. We'll also send a short weekly evidence update — unsubscribe any time.