Educational information, not medical advice — ask your doctor or midwife.
Zhi Shi Xie Bai Gui Zhi Tang is a classical Chinese herbal formula taken as a decoction (herbs simmered in water and drunk as a tea). It is used in traditional practice for a tight, heavy or squeezing feeling in the chest, sometimes with pain that spreads to the back, and with burping or a bloated upper belly.
Our records list it as: Single drug (TCM formula). Also known as: Immature Bitter Orange, Chinese Chive, and Cinnamon Twig Decoction. It normally contains five herbs: zhi shi (unripe bitter orange), xie bai (Chinese chive bulb), gui zhi (cinnamon twig), gua lou (snake gourd fruit) and hou po (magnolia bark).
Here is the evidence in one line: this formula has a long, well-documented history in Chinese medicine, but there are no good human trials showing that it works. Long use in a tradition is not proof of effect, and you will not see that point repeated in every section below.
One warning belongs at the very top. Chest pain and chest tightness can mean a heart attack or another serious heart or lung problem.
Do not treat new, bad or changing chest symptoms with herbs. Get checked by a doctor first.
Nobody has shown in people how this formula works. What follows is the traditional idea plus what lab work hints at, and neither one proves an effect in your body.
In Chinese medicine terms, the formula is said to move "qi" (a traditional idea of flow or energy) that has become stuck in the chest, and to warm and open the chest. Zhi shi and hou po are the movers, xie bai and gua lou are said to open the chest, and gui zhi warms it.
In a modern lab, the parts do have measurable actions. Bitter orange contains synephrine, a mild stimulant that can raise heart rate and blood pressure. Cinnamon twig and magnolia bark compounds relax smooth muscle in test dishes and animals.
Those lab findings are a long way from a benefit you would feel. They also cut both ways: the same stimulant action that shows up in a lab is the reason this formula is risky for anyone with a heart condition.
The traditional form is a water decoction. A practitioner weighs out raw sliced herbs, and you simmer them and drink the strained liquid.
Other forms you may be offered:
Granules, where the decoction is dried into a powder you dissolve in hot water. Pills or tablets made from concentrated extract. Pre-made liquid vials, less common outside China.
Granules and pills are easier to take, but the strength varies a lot between makers. There is no agreed standard extract, so two products with the same name can differ.
The formula comes from the Jin Gui Yao Lue (Essential Prescriptions of the Golden Cabinet), written by Zhang Zhongjing in China around 200 CE. It sits in the chapter on "chest bi", the classical name for chest tightness and pain.
It has stayed in continuous use in Chinese medicine for roughly eighteen centuries and appears in modern Chinese formula textbooks. It is a staple of one tradition, not a remedy shared across several.
Some reactions to Zhi Shi Xie Bai Gui Zhi Tang need urgent care. Call your local emergency number or go to an emergency department straight away — do not wait to see whether it passes.
Call emergency services right away if you have chest pain that is crushing, spreads to your arm, jaw, neck or back, or comes with sweating, sickness, or trouble breathing. That may be a heart attack. Do the same for a very fast or pounding heartbeat, fainting, or sudden weakness or slurred speech.
Stop taking it and see a doctor the same week if you notice a racing heart, higher blood pressure readings, bad headaches, or dizziness.
Stop and see a doctor if your skin or eyes look yellow, your urine turns dark, or you get pain in your upper right belly. These can be signs of liver trouble.
See a doctor if your chest symptoms have not settled after two weeks, or if they come back, get worse, or start waking you at night.
Evidence grades and traditional-use labels are explained in our methodology. Nothing here is medical advice.
What it is typically used for, usual dose, cautions, and the study behind it where real trial data exists.
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