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Renjuin

Traditionally used for: Traditional Kampo care for dizziness with tiredness, under a prescriber. Dizziness and lightheadedness; Palpitations.

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What is Renjuin? Renjuin is a herbal formula from Kampo, the traditional medicine of Japan. Its name means "string-of-pearls drink". It is given for dizziness, lightheadedness and a fluttering heartbeat. Renjuin joins two older formulas. One is ryokeijutsukanto, long used for dizziness and palpitations. The other is shimotsuto, long used for pallor, tiredness and period problems. It is a ministry-approved Kampo formula in Japan. In practice a Kampo doctor chooses it for a person, not for a disease name alone. Here is the plain verdict. Renjuin has a long record in Japan, but we found no controlled human trials of the formula. Traditional use is not proof that a remedy works. Safety, not benefit, is the main point of this page. Renjuin contains kanzo (licorice), and licorice has real, documented risks in people. How does Renjuin work? Kampo explains Renjuin in its own terms. It is said to move stagnant "water" and to build "blood". These are traditional ideas, not measured body chemistry. Modern mechanism work on the whole formula is sparse. We found no studies that test how Renjuin as a blend acts in the human body. One part is well understood. Glycyrrhizin, from kanzo (licorice), blocks an enzyme in the kidney. In people this leads the body to hold salt and water and to lose potassium. Doctors call that pattern pseudoaldosteronism (a false hormone-like state that holds salt and drops potassium). This is a proven human effect, not a lab-only finding. The other herbs have been looked at mainly in test tubes and animals. Peony and cnidium extracts appear to relax blood vessels in animal work. Whether that happens in people taking Renjuin is not known. What forms does Renjuin come in? Most people meet Renjuin as a granulated extract in sachets. Licensed Japanese makers supply it as an approved Kampo product. We could not confirm a specific maker's product number, so none is given here. It also exists as a fine powder, as tablets, and as a decoction (herbs boiled in water). The decoction is the older form and is still used by some practitioners. Supply outside Japan is patchy. Imported products vary in strength and in how much licorice they contain. Where it comes from: Renjuin is a Japanese formula built from two Chinese classics. Ryokeijutsukanto comes from the Han-era Shang Han Lun. Shimotsuto comes from a Song-era formulary. Japanese doctors combined the two during the Edo period. The joined formula was used for dizzy, pale, easily tired patients. It stayed in use and is now an approved Kampo formula in Japan's health system.

Helps

What does Renjuin help with? Dizziness and lightheadedness: This is the classic Kampo use. The formula is picked for people who feel unsteady and washed out. We found no controlled trial testing Renjuin for dizziness. Palpitations (a pounding or fluttering heartbeat): Ryokeijutsukanto, one half of the blend, is traditionally used for this feeling. New or severe palpitations need a doctor first. No trial supports Renjuin for this. Dizziness on standing up: Kampo practice uses Renjuin for people who go grey or swim-headed when they rise. Trial evidence is absent. Low blood pressure and anaemia should be ruled out by a doctor. Tiredness with pale skin: Shimotsuto, the other half, is the classic "blood-building" formula in Kampo. This is a traditional idea, not proof of an effect on blood counts. Pale skin with tiredness may mean anaemia, which needs testing. Period-related dizziness and fatigue: Renjuin is often chosen for women with light-headedness around their period. The use is traditional and widely reported by Kampo doctors. We found no controlled trials. Cold hands and feet: Kampo links cold limbs with weak "blood" and uses shimotsuto-type formulas for it. Evidence is limited to traditional practice and case reports.

Renjuin

Quick Facts

  • What it is: Renjuin is a Japanese Kampo herbal formula, made of ryokeijutsukanto plus shimotsuto, used for dizziness, palpitations and tiredness.
  • Main uses: Dizziness and lightheadedness, Palpitations, Tiredness with pale skin, Period-related dizziness
  • Best for: Traditional Kampo care for dizziness with tiredness, under a prescriber
  • Active ingredients: Glycyrrhizin (from kanzo/licorice), Paeoniflorin (from shakuyaku), Cinnamaldehyde (from keihi), Ferulic acid (from toki), Catalpol (from jio)
  • Forms: Granulated extract sachets, Fine powder, Tablets, Decoction (herbs boiled in water)
  • Time to effect: Not established; Kampo practice expects days to a few weeks.
  • Side effects: Mild stomach upset is common; licorice can cause swelling, high blood pressure, low potassium and muscle damage.
  • Pregnancy & breastfeeding: Avoid in pregnancy and while breastfeeding.

Educational information, not medical advice — ask your doctor or midwife.

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What is Renjuin?

Renjuin is a herbal formula from Kampo, the traditional medicine of Japan. Its name means "string-of-pearls drink". It is given for dizziness, lightheadedness and a fluttering heartbeat.

Renjuin joins two older formulas. One is ryokeijutsukanto, long used for dizziness and palpitations. The other is shimotsuto, long used for pallor, tiredness and period problems.

It is a ministry-approved Kampo formula in Japan. In practice a Kampo doctor chooses it for a person, not for a disease name alone.

Here is the plain verdict. Renjuin has a long record in Japan, but we found no controlled human trials of the formula. Traditional use is not proof that a remedy works.

Safety, not benefit, is the main point of this page. Renjuin contains kanzo (licorice), and licorice has real, documented risks in people.

How does Renjuin work?

Kampo explains Renjuin in its own terms. It is said to move stagnant "water" and to build "blood". These are traditional ideas, not measured body chemistry.

Modern mechanism work on the whole formula is sparse. We found no studies that test how Renjuin as a blend acts in the human body.

One part is well understood. Glycyrrhizin, from kanzo (licorice), blocks an enzyme in the kidney. In people this leads the body to hold salt and water and to lose potassium.

Doctors call that pattern pseudoaldosteronism (a false hormone-like state that holds salt and drops potassium). This is a proven human effect, not a lab-only finding.

The other herbs have been looked at mainly in test tubes and animals. Peony and cnidium extracts appear to relax blood vessels in animal work. Whether that happens in people taking Renjuin is not known.

What forms does Renjuin come in?

Most people meet Renjuin as a granulated extract in sachets. Licensed Japanese makers supply it as an approved Kampo product. We could not confirm a specific maker's product number, so none is given here.

It also exists as a fine powder, as tablets, and as a decoction (herbs boiled in water). The decoction is the older form and is still used by some practitioners.

Supply outside Japan is patchy. Imported products vary in strength and in how much licorice they contain.

Where it comes from:

Renjuin is a Japanese formula built from two Chinese classics. Ryokeijutsukanto comes from the Han-era Shang Han Lun. Shimotsuto comes from a Song-era formulary.

Japanese doctors combined the two during the Edo period. The joined formula was used for dizzy, pale, easily tired patients.

It stayed in use and is now an approved Kampo formula in Japan's health system.

If this is an emergency

Some reactions to Renjuin need urgent care. Call your local emergency number or go to an emergency department straight away — do not wait to see whether it passes.

Who should avoid Renjuin?

  • Do not use if you have low potassium (hypokalaemia), whether or not you feel unwell
  • Do not use if you have aldosteronism (a hormone disorder that raises blood pressure and lowers potassium)
  • Do not use if you have high blood pressure that is not under control
  • Do not use if you have had myopathy (muscle weakness and muscle damage) from licorice before
  • Do not use if you are pregnant or breastfeeding
  • Do not use if you take digoxin (a heart medicine), water tablets or steroid medicines, unless a doctor is supervising you and checking your potassium
  • Do not use if you have heart failure, kidney disease or liver disease
  • Do not use if you already take another product that contains licorice or kanzo
  • Do not give it to a child except on a doctor's instruction
  • Never keep taking it after your ankles swell or your muscles turn weak

When should you see a doctor?

Get medical help the same day if your ankles or face swell, if you gain weight fast, or if your muscles feel weak or cramp.

Go to an emergency department if your urine turns dark or cola-coloured, if your heart pounds or skips, or if you faint.

See a doctor promptly for yellow skin or eyes, or for a new dry cough with fever and breathlessness.

See a doctor before you start if your dizziness is new, severe, or comes with chest pain, slurred speech or a bad headache.

Evidence grades and traditional-use labels are explained in our methodology. Nothing here is medical advice.

Reviewed by the HealisticMD editorial team How we grade evidence →

The published evidence for Renjuin is weak or absent. That usually means no controlled trial has tested it, not that a trial found it ineffective — the two are different, and we grade only what has been published.

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